Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy.
نویسندگان
چکیده
We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 19 شماره
صفحات -
تاریخ انتشار 2014